Appletini
A running gag (from 2001) · J.D. (John Dorian)
J.D.'s fondness for appletinis is a recurring punchline, often about his masculinity.
Sources: Eater - When Did America Turn on the Appletini?; Paste - Great Moments in TV Drinking: Mr. Robot Resurrects the Appletini; Wikipedia - Appletini (In popular culture)