The difference, by the numbers
Both have simple syrup. Only the Siesta has tequila, lime juice, grapefruit juice and Campari; only the Whiskey Sour has bourbon and lemon juice. In parts, a Siesta is 3 tequila, 1½ lime, 1 grapefruit, 1½ syrup and ½ Campari; a Whiskey Sour is 2¼ whiskey, 1¼ lemon and 1 syrup. By volume, the Siesta is 40% spirit, 33% citrus, 20% syrup and sugar and 7% fortified wine and bitter; the Whiskey Sour is 50% spirit, 28% citrus and 22% syrup and sugar. That makes them close cousins on the ratio map.
The Whiskey Sour is the stronger drink in the glass (13.4% ABV against 11.5%), but being smaller it holds about the same alcohol (1.12 and 1.14 standard drinks). The Siesta has more calories (about 182 against 168) and more sugar (17.5 g against 13.0 g). Both are shaken and served in a coupe.